
A fish breeding box keeps fry alive through the days when everything in the tank, including their parents, treats them as food. It is also an enclosure with restricted water exchange, which makes it the easiest place in the tank for waste to concentrate. Used well it saves a batch; used carelessly it becomes the worst water in the aquarium.
Three jobs: isolating a heavily pregnant livebearer so fry are born safely, holding newborn fry away from adults, and separating an injured or bullied fish without moving it to another tank. Livebearers — guppies, mollies, platies — are the usual reason, because they deliver free-swimming fry that adults eat within minutes.
Floating and suspended acrylic boxes sit inside the tank and share its temperature, which removes any acclimation shock. Hang-on external boxes give more volume and better flow but need their own water supply from the filter outflow. For a first attempt, an in-tank box is simpler and harder to get wrong.
Because fry in a confined volume produce waste that has nowhere to go. Slotted or mesh sides let tank water exchange continuously; a solid-walled box becomes a stagnant pocket where ammonia rises invisibly. Ammonia causes stress and damages gills at low concentrations, with tissue damage above 0.05 mg/L — and fry show it first. See the small fish tank guide for how cycling keeps that figure at zero.
Until they are too large to fit in an adult’s mouth, usually two to four weeks depending on species and growth. Keeping them confined longer stunts growth, because a small volume limits both swimming and feeding. Move them to a grow-out tank or a heavily planted corner as soon as size allows.
Food small enough to fit, several times a day. Crushed flake, powdered fry food, infusoria and live cultures all work depending on species. Live foods are the traditional answer for the smallest fry — UF/IFAS documents Moina as ideal for feeding freshwater fish fry, with young individuals small enough for newly hatched fish to take. Feed little and often, and siphon leftovers.

See the small fish tank guide and the aquarium filter guide, or browse Fish & Aquatic Pets.
As late as you can judge it, and out immediately after birth. Confining a pregnant female for days is stressful enough to delay or abort delivery, and once fry arrive she will eat them like any other adult. A box with a fry-safe lower chamber solves the timing problem by separating them automatically.

Not if the tank is densely planted. Thick cover lets a reasonable proportion of fry survive without intervention.
For isolation yes, for medication no — dosing the box means dosing the whole tank, since water exchanges freely.
Fewer than it looks. Crowding stunts growth and fouls the water; split large batches across two boxes.
Usually poor water exchange or overfeeding. Check flow through the slots and siphon uneaten food daily.
Often a spawning mop or separate tank suits them better, since eggs need a surface rather than confinement.
Only if neither is aggressive. Confinement intensifies territorial behaviour rather than defusing it.
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